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Thermoplastic polymers (10), ensuring lower fabrication costs per device and hence favoring disposability in order to prevent Mass production techniques such as injection molding are highly suitable for fabrication of microfluidic devices based onĬomprehensive Materials Processing, Volume 13ĭevelopments of Laser Fabrication Methods for Lab-on-a-Chip Microfluidic Multisensing Devices Transparent, which is an important requirement for successful integration of optical detection with microfluidic devices. Compared with silicon, glass (e.g., quartz, fused silica, and borosilicate) and polymers are optically Microfabrication technologies have been developed for the production of microchannels and other microfluidic components in Ever since then, a wide range of alternative
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Materials with different chemical, mechanical, electrical, and optical properties. Microfluidic devices has grown exponentially in the last decade as a result of a significant increase in the availability of polymeric However, the use of polymeric materials for fabrication of The semiconductor industry, namely, photolithography and etching (8,9). Microfluidic devices were initially fabricated from silicon and glass materials using microfabrication techniques developed within Special attention will be given to the many advances occurring in laserįabrication of microchannels and other microfeatures during recent decades, since this technology has emerged as a powerful toolįor micromachining a diverse set of materials.Ĭommon Materials Employed in the Fabrication of Microfluidic Devices Microfluidic device manufacturing will be discussed. In this chapter, existing technologies used for fabrication of microchannels from a wide range of materials for the purpose of Platforms have found application in almost all ‘hot’ scientific disciplines over the past decade, including medical diagnostics, drugĭiscovery, environmental and clinical analysis, proteomics, genetics, and forensics (1,3–7). Miniaturization also facilitates the integration of parallel architectures in a single device for realization of high-throughput analysis,Īs demonstrated in a recent work where 1450 immunoassays were performed in less than 40 min (2).
EASE DIAGNOSTICS MAJEC EMISSION MACHINES PORTABLE
Portable devices, with potential applications in point-of-care diagnostics and on-site environmental or process monitoring. More over, the small dimensions of microfluidic platforms ease their integration into completely self-contained, highly Possibility of working with samples that are available only at very low quantities (e.g., biological samples such as cerebrospinal Volumes of toxic wastes will be generated (3) economic savings resulting from lower sample and reagent consumption and (4) the Safety when dealing with harmful or toxic samples or reagents (2) improved environmental protection because much lower Working with small volumes of sample, solvents, and reagents brings additional benefits such as (1) improved personal Several analytical operations (e.g., extraction, mixing, separation, incubation, and detection) into a single device (i.e., a lab on a chip In addition to speed of analysis, microfluidic platforms also present other importantĪdvantages such as improved mass and heat transfer, low volume requirements for samples and reagents, and the ability to integrate
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Order of tens to hundreds of micrometers. Typically a few square centimeters in size, microfluidic devices integrate channels with dimensions usually on the
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Microfluidics is a discipline focused on the control and manipulation of very small fluid volumes on the order of a few microliters toĮven picoliters. Laser Precision Engineering of Microfluidic Channels Standard Fabrication Methods for Microfluidic Devices All rights reserved.Ĭommon Materials Employed in the Fabrication of Microfluidic Devices 13.17 Developments of Laser Fabrication Methods for Lab-on-a-ChipĪB Azouz, M Vázquez, and D Brabazon, Dublin City University, Dublin, Ireland